The modern approach to teaching chemical biology Advanced Chemical
Biology is organized around the central dogma of life, progressing
from genes to proteins and higher-order cellular structures,
including core application areas such as imaging, chemical
genetics, activity-based protein profiling, and natural product
discovery and biosynthesis. Advanced topics and applications in, e.
g., microbiology, developmental biology, and neurobiology, are
covered in separate sections. Every chapter is homogeneous in style
and layout, consisting of a short historical introduction followed
by a description of the underlying concepts and a selection of
recent examples of how the concept has been turned into practice.
The subdivision of the contents into core and supplemental chapters
enables a flexible use in teaching, both for a one-semester and a
two-semester course. Written by authors and editors coming from the
leading scientific institutions that have developed the concepts
and technologies for this discipline, Advanced Chemical Biology
includes specific information on topics like: DNA function,
synthesis and engineering, chemical approaches to genome integrity,
and RNA function, synthesis, and probing Chemical approaches to
transcription and RNA regulation in vivo, chemical biology of
genome engineering, and peptide/protein synthesis and engineering
Directed evolution for chemical biology, chemical biology of
cellular metabolism, chemical biology of lipids, and protein
post-translational modifications Chemical glycobiology, chemical
and enzymatic modification of proteins, genetic code expansion,
bio-orthogonal chemistry, and cellular imaging With its broad scope
and focus on turning concepts into applications, Advanced Chemical
Biology is an excellent starting point for anyone entering the
field and looking for a guide to the wide range of available
methods and strategies that chemical biology has to offer.
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