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Handbuch Der Experimentellen Pharmakologie -- Erganzungswerk - Funfter Band (German, Paperback, 1937 ed.)
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Handbuch Der Experimentellen Pharmakologie -- Erganzungswerk - Funfter Band (German, Paperback, 1937 ed.)
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195 in the coronary flow of the perfused cat's heart. KREITMAIR
confirmed this action by a different method. Using heart-lung
preparation in dogs with a MORAWITZ coronary canula, he found that
harmol (10 mgm. per Kilo) produced 1 a remarkable increase in the
coronary flow. BRAMWELL, CAMPBELL and EVANS treated 20 patients
suffering from angina pectoris with propylharmol by mouth and found
benefit from the drug in four early cases but no improvement in the
more severe types. Seven out of 41 cases of angina, treated by
harmol hydro chloride by mouth, appeared to be improved.
Comparative Actions on the Uterus. The stimulant action on the
uterus, first observed with harmaline, was investigated
subsequently with other compounds with a view to determining
QUi"i." l,""rl111Olol Quill;'''' QlIillillC IIarmnlol I mg per
kilo. J mg per kilo. In/( per kilo. a mg per kilo. 0.3 mg /ler
kilo. Fig.5. Rabbit, non.pregnant, anaesthetised by urethane;
contractions of uterus recorded in situ; varying doses of harmalol
and quinine intravenously. Showing that 0.3 mgm. per kgm, harmalol
in about equnl, in activity on the uterus, to 5.0 mgm. quinine."
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