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Hormones and Resistance - Part 1 and Part 2 (Paperback, Softcover reprint of the original 1st ed. 1971)
Loot Price: R3,903
Discovery Miles 39 030
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Hormones and Resistance - Part 1 and Part 2 (Paperback, Softcover reprint of the original 1st ed. 1971)
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7 If so, the individual members of each class thus identified could
then be subjected to a more profound pharmacokinetic analysis. In
other words, we had to determine first which hormone protects
against which drug, before we could explore how it did this. We had
to know first that a hormone has adaptive value before we could ask
whether this is due to a syntoxic or a catatoxic mechanism. Such
observations, as the fact that an indomethacin-induced intestinal
ulcer can be prevented by ethylestrenol, orthat cortisol aggravates
certain infections, reveal nothing about how these hormones work;
but only findings of this type can tell us where further research
would be rewarding. Of course, scientists can rarely identify by
direct observation the tbings that they are looking for; most of
the time they have to be guided by indirect indices. The ebernist
often first detects a compound, or even a particular functional
group in its molecule, by inference from a color reaction, a
revealing X-ray diffraction pattern or the formation of a
characteristic precipitate. The physician must first suspect the
presence of a microbe through certain clinical signs and symptoms
before he can verify his diagnosis by looking for a particular
organism. It is perhaps not too daring to hope that in our first
efforts to clarify the role of hormones in resistance, simple,
directly visible indicators might also serve us best.
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