Third Generation EGFR Inhibitors - Overcoming EGFR Resistance and Toxicity Problems (Paperback)

Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics.

General

Imprint:	Elsevier / The Lancet
Country of origin:	United Kingdom
Release date:	December 2018
First published:	2019
Authors:	Harun M. Patel • Rahul Pawara • Sanjay J. Surana
Dimensions:	229 x 152 x 19mm (L x W x T)
Format:	Paperback
Pages:	208
ISBN-13:	978-0-08-102661-8
Categories:	Books > Medicine > Other branches of medicine > Pharmacology > General Books > Science & Mathematics > Chemistry > Organic chemistry > General
LSN:	0-08-102661-7
Barcode:	9780081026618

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