Lung cancer is one of the biggest challenges in oncology today. The
challenge is due to the recognition of the possibility of
prevention in at least 70-80 % of all the cases and the extreme
difficulties encountered in the treatment of this neoplasm. Despite
the knowledge of prevention measures such as cessation of cigarette
smoking the incidence continues to increase in many countries. The
increase is particularly notable in females in the west ernized
countries where the death rate in females in certain regions sur
passes that of breast cancer. Furthermore, in many developing
countries lung cancer is now being diagnosed with increasing
frequency in both sexes and it is expected to be a major cause of
death in those countries later in this century or the beginning of
next century if the tobacco consumption will continue its rapid
rise. With respect to therapy the 1970'es brought considerable
progress in understanding of the clinical behaviour of lung cancer
thereby establishing the importance of distinguishing between the
major histologic types. Thera peutic advancement was particularly
experienced in small cell carcinoma with the introduction of
combination chemotherapy after this special dis ease entity among
lung cancers was recognized as being a disseminated dis ease in
almost all cases at the time of diagnosis. It was expected that the
improvement in therapy would have continued in the early 1980'es,
not only for small cell lung cancer but also for the other cell
types."
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