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Fine-Tuning of RNA Functions by Modification and Editing (Paperback, Softcover reprint of hardcover 1st ed. 2005)
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Fine-Tuning of RNA Functions by Modification and Editing (Paperback, Softcover reprint of hardcover 1st ed. 2005)
Series: Topics in Current Genetics, 12
Expected to ship within 9 - 15 working days
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Naturally occurring RNA always contains numerous biochemically
altered nucleotides. They are formed by enzymatic modification of
the primary transcripts during the complex RNA maturation process
designated RNA modification. A large number of enzymes catalyzing
the formation of these modified nucleosides or converting one
canonical base into another at the posttranscriptional level have
been studied for many years, but only recently have systematic and
comparative studies begun. The functions of individual enzymes
and/or the modified/edited nucleosides in RNA, however, have
remained largely ignored. This book provides advance information on
RNA modification, including the associated editing machinery, while
offering the reader some perspective on the significance of such
modifications in fine-tuning the structure and functions of mature
RNA molecules and hence the ability to influence the efficiency and
accuracy of genetic expression. Outstanding scientists who are
actively working on RNA modification/editing processes have
provided up-to-date information on these intriguing cellular
processes that have been generated over the course of millions of
years in all living organisms. Each review has been written and
illustrated for a large audience of readers, not only specialists
in the field, but also for advanced students or researchers who
want to learn more about recent progress in RNA modification and
editing.
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