Mitochondrial DNA and Diseases (Hardcover, 1st ed. 2017)

The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing. Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinical students and researchers in the field of mtDNA-associated diseases.

General

Imprint:	Springer Verlag, Singapore
Country of origin:	Singapore
Series:	Advances in Experimental Medicine and Biology, 1038
Release date:	December 2017
First published:	2017
Editors:	Hongzhi Sun • Xiangdong Wang
Dimensions:	235 x 155mm (L x W)
Format:	Hardcover
Pages:	230
Edition:	1st ed. 2017
ISBN-13:	978-981-10-6673-3
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
LSN:	981-10-6673-6
Barcode:	9789811066733

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