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Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles (Hardcover, 1st ed. 2020)
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Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles (Hardcover, 1st ed. 2020)
Series: Springer Theses
Expected to ship within 10 - 15 working days
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This book presents Pd- and Ni-catalyzed transformations generating
functionalized heterocycles. Transition metal catalysis is at the
forefront of synthetic organic chemistry since it offers new and
powerful methods to forge carbon-carbon bonds in high atom- and
step-economy. In Chapter 1, the author describes a Pd- and
Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides,
known as carboiodination. In the context of the Pd-catalyzed
variant, the chapter explores the production of enantioenriched
carboxamides through diastereoselective Pd-catalyzed
carboiodination. It then discusses Ni-catalyzed reactions to
generate oxindoles and an enantioselective variant employing a dual
ligand system. Chapter 2 introduces readers to a Pd-catalyzed
diastereoselective anion-capture cascade. It also examines
diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl
nitriles, a method that generates high yields of borylated chromans
as a single diastereomer, and highlights its synthetic utility.
Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing
carbopalladation, C-H activation and -system insertion (benzynes
and alkynes) to generate spirocycles. It also describes the
mechanistic studies performed on these reactions.
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