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Books > Medicine > Pre-clinical medicine: basic sciences
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Genomics III - Methods, Techniques and Applications (Paperback)
Loot Price: R2,109
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Genomics III - Methods, Techniques and Applications (Paperback)
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Genomics is the study of the genomes of organisms. The field
includes intensive efforts to determine the entire DNA sequence of
organisms and fine-scale genetic mapping efforts. It is a
discipline in genetics that applies recombinant DNA, DNA sequencing
methods, and bioinformatics to sequence, assemble, and analyse the
function and structure of genomes. Genomics III - Methods,
Techniques and Applications is the last volume of our Genomics
series.
Chapter 1 presents an overview of exome sequencing technology and
details its use in identification of molecular bases of rare
diseases in human.
Chapter 2 describes and compares different methods of whole genome
amplification (WGA) for replenishing DNA samples for genetic
studies.
Chapter 3 ilustrates the method of whole genome microarray gene
expression profiling and its application to study the treatment
effect of a widely used cardiovascular drug.
Chapter 4 describes a brief history of large-insert libraries and
their utility in exploring organisms with poor genetic and genome
information.
Chapter 5 proposes a bio-molecular approach for the evaluation of
the anaerobic digestion performance.
In Chapter 6, quantitative issues of the transposon-based gene
delivery methods are addressed. Using the "Sleeping Beauty"
transposon system as a prominent example, special detailed focus is
given to copy number determination and to transposon excision
efficiency quantification by real-time PCR based methodologies.
Chapter 7 provides an overview of extraction of a compendium of
sequence and structural features, as well as the methodology for
function prediction based on the techniques from Artificial
Intelligence and Machine learning.
Chapter 8 presents a statistical method and a data mining solution
for the problem of insertion site analysis and characterization of
Alu elements
Chapter 9 investigates how Mutual Information (MI) can be used to
improve methods of predicting functional residues and enhance
structural data to describe the topological properties of amino
acid coevolution networks within a protein and their interactions.
Chapter 10 attempts to validate MLVA to see if it could predict
MRSA clones that were previously characterized by PFGE, MLST, and
staphylococcal cassette chromosome mec (SCCmec) typing and to
establish possible criteria of clustering MLVA patterns, looking
for high concordance levels.
Chapter 11 introduces a web server which allows the user to
perform genome rearrangement analysis using reversals,
block-interchanges (also called generalized transpositions) and
translocations (including fusions and fissions).
Chapter 12 discussed an algorithm which is used to optimally align
simple sequence repeat (microsatellite) regions as they evolve
uniquely through a process called polymerase slippage.
Chapter 13 possesses a background of the RUN domain research with
an emphasis on the interaction between RUN domain protein including
RUFY proteins and small GTPases with respect to the cell polarity
and membrane trafficking.
In Chapter 14, the authors detail recent advances in understanding
mechanisms of gene regulation in Drosophila.
Chapter 15 provides guidelines for human molecular geneticists to
perform genetic screenings using next generation sequencing.
Chapter 16 describes the process that was used to locate and
characterize small group I introns in the rRNA gene locus of fungi.
Chapter 17 summarizes recent insights in the biology of variant
gene transcription in human and murine malaria species and
addresses the molecular mechanisms at work which regulate the
expression of important virulence factors.
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