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Measuring Dynamic Network Interactions that Control Pituitary Gene Expression (Paperback)
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Discovery Miles 14 000
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Measuring Dynamic Network Interactions that Control Pituitary Gene Expression (Paperback)
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The combinatorial interactions of the homeodomain protein Pit-1
with transcription factors such as C/EBPalpha and with coregulatory
proteins control the development of anterior pituitary cells. These
cells fail to develop in individuals with mutations affecting the
Pit-1 gene, resulting in combined pituitary hormone deficiency. The
present work describes biochemical, live-cell imaging and in vivo
kinetics studies that provide new insight into the dynamic network
interactions inside the pituitary-cell nucleus. The findings
reported here support a model where proteins move independently
within the nuclear compartment and stochastically associate at
specific intranuclear sites as part of metastable complexes. The
probability that these proteins assemble in a particular region of
the cell nucleus is related to the dominant chromatin-binding
activities of the different protein partners, supporting the view
that the repositioning of transcription factors and coregulators
represents an important mechanism for directing changes in
cell-specific gene expression. These studies also suggest an
important link between the mislocalization of transcriptional
complexes and disease processes.
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