APC Proteins (Hardcover, 2009 ed.)

The initial identification of the Adenomatous polyposis coli (Apc) gene as the site of mutations in familial adenomatous polyposis (FA P) was described in 1992. A causal relationship between Apc mutations and intestinal tract tumours was confirmed three years later with the establishment of the Min mouse model. These mice are heterozygous for Apc and develop numerous intestinal tumours that mimic FA P. Subsequently, Apc has emerged as the most commonly mutated gene in colorectal cancer with reports varying between 50-80% of sporadic tumours carrying such mutations. The search for how mutations in Apc initiate and/or support progression of tumours in the intestinal tract has revealed that the Apc protein is a multifunctional participant in a diverse array of cellular functions. By collecting and assembling the chapters in this book, we aimed to provide an overview of the diverse functions performed by the Apc protein. As summarised in a short final chapter by Trainer, heterozygosity of Apc leads to a number of extracolonic manifestations that further support this emerging picture of the Apc protein as an active contributor to many different cellular functions. The first recognised function of Apc was its role in Wnt signalling. This function is one of the driving forces for how mutations in Apc ensure that cells remain proliferative. Many of the molecular details of this pathway have been discovered and are described in the first chapter by Kennell and Cadigan. The transcriptional changes that result from Apc mutations due to changes in the transcriptional contribution of -catenin are exacerbated by direct functions of Apc in the nucleus, which are discussed by Neufeld. The transcriptional changes induced by mutant Apc provide the background against which other cellular functions of Apc become particularly important in the digestive tract epithelium. Cell migration contributes significantly to the normal maintenance of this tissue, a

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Series:	Advances in Experimental Medicine and Biology, 656
Release date:	September 2009
First published:	2009
Editors:	Inke S. Nathke • Brooke M. McCarthney
Dimensions:	235 x 155 x 15mm (L x W x T)
Format:	Hardcover
Pages:	148
Edition:	2009 ed.
ISBN-13:	978-1-4419-1144-5
Categories:	Books > Medicine > General issues > Medical equipment & techniques > Medical research Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
LSN:	1-4419-1144-8
Barcode:	9781441911445

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!