Evaluates the carcinogenic risk to humans posed by occupational
exposure during the spraying and application of insecticides. The
book also features separate monographs evaluating the
carcinogenicity of 17 individual pesticides, including several that
have been banned by industrialized countries yet are still used in
the developing world. Although some of these pesticides have been
in use for more than four decades, evaluations of carcinogenicity
were hindered by the sparsity of well-designed epidemiological
studies. The first and most extensive monograph evaluates data from
descriptive and ecological studies, cohort studies, and
case-control studies suggesting an increased risk of cancer, most
notably lung cancer, multiple myeloma and other tumours of B-cell
origin, in workers exposed to insecticides during their
application. On the basis of this evaluation, the book concludes
that the spraying and application of nonarsenical insecticides
entail exposures that are probably carcinogenic to humans. The
remaining monographs evaluate the carcinogenicity of aldicarb,
atrazine, captafol, chlordane, DDT, deltamethrin, dichlorvos,
fenvalerate, heptachlor, monuron, pentachlorophenol, permethrin,
picloram, simazine, thiram, trifluralin, and zitram. Of these,
captafol, a fungicide used on plants, for seed treatment, and as a
wood preservative, was classified as probably carcinogenic to
humans. Atrazine, chlordane, DDT, dichlorvos, heptachlor, and
pentachlorophenol were classified as possibly carcinogenic to
humans. The remaining pesticides could not be classified on the
basis of available data.
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