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Metabolic Networks, Elementary Flux Modes, and Polyhedral Cones (Paperback)
Loot Price: R1,750
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Metabolic Networks, Elementary Flux Modes, and Polyhedral Cones (Paperback)
Series: Other Titles in Applied Mathematics
Expected to ship within 12 - 17 working days
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Expositions of quantitative methods and algorithms for biological
data tend to be scattered through the technical literature, often
across different fields, and are thus awkward to assimilate. This
book documents one example of this: the relationship between the
cell biology idea of metabolic networks and the mathematical idea
of polyhedral cones. Such cones can be used to describe the set of
steady-state admissible fluxes through metabolic networks, and
consequently have become important constructs in the field of
microbiology. Via convex cone concepts, fundamental objects called
elementary flux modes (EFMs) can be described mathematically. The
fundamental algorithm of this relationship is the double
description method, which has an extended history in the field of
computational geometry. This monograph addresses its relatively
recent use in the context of cellular metabolism. Metabolic
Networks, Elementary Flux Modes, and Polyhedral Cones: Addresses
important topics in the mathematical description of metabolic
activity that have not previously appeared in unified form.
Introduces a central topic of mathematical systems biology in a
manner accessible to nonmathematicians with some mathematical and
computational experience. Presents a careful study of the double
description method, a fundamental algorithm of computational
geometry, in the context of metabolic analysis. The core audience
for this book includes mathematicians, engineers, and biologists
interested in cell metabolism. Computational geometers will also
find it of interest.
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