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Drug Receptor Interactions in Antimicrobial Chemotherapy - Symposium, Vienna, September 4-6, 1974 (Paperback, Softcover reprint of the original 1st ed. 1975)
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Drug Receptor Interactions in Antimicrobial Chemotherapy - Symposium, Vienna, September 4-6, 1974 (Paperback, Softcover reprint of the original 1st ed. 1975)
Series: Topics in Infectious Diseases, 1
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List price R2,596
Loot Price R577
Discovery Miles 5 770
You Save R2,019 (78%)
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The concept of chemotherapy as originated by Paul Ehrlich is based
on the premise that antiparasitic drugs must have two properties:
they must first bind to specific structures of the parasite which
Ehrlich called chemoreceptors. Subsequent to their attachment to
the chemoreceptor and by virtue of this binding they must possess
the capacity to kill the parasite. Since the host which is to be
cured of an invading parasite also contains a large number of
chemoreceptors, that have the potential to bind toxic compounds,
the task of the chemo therapist is to identify chemoreceptors of
the parasite which are . not represented in the host and to design
drugs which bind selectively to them In this context, Ehrlich
called. for "the complete and exhaustive knowledge of all the
different chemoreceptors of a certain parasite" as a "sine qua non
for success in chemotherapy." Paradoxically and in spite of the
fact that chemotherapy has become a very advanced and successful
therapeutic discipline, few of its tri umphs have been achieved by
following Ehrlich's original precepts. On the contrary, in the
overwhelming majority of cases, effective drugs have been
discovered without any knowledge of their chemoreceptors, and these
drugs themselves have conversely been used as tools to study the
nature of the chemoreceptors involved. In other words: chemother
apy, notably antibacterial chemotherapy, has been successful
without ever living up to the fundamental standards put forward by
Paul Ehr lich."
General
Imprint: |
Springer-Verlag
|
Country of origin: |
Austria |
Series: |
Topics in Infectious Diseases, 1 |
Release date: |
2012 |
First published: |
1975 |
Editors: |
J. Drews
• F. E. Hahn
|
Dimensions: |
244 x 170 x 17mm (L x W x T) |
Format: |
Paperback
|
Pages: |
314 |
Edition: |
Softcover reprint of the original 1st ed. 1975 |
ISBN-13: |
978-3-7091-8407-3 |
Categories: |
Books >
Medicine >
General issues >
General
|
LSN: |
3-7091-8407-X |
Barcode: |
9783709184073 |
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