The study of prenatal development provides many clues for
understanding the physiology as well as the pathogeny of
malformations and many diseases. I became interested in the
analysis of human development as a young medical student more than
30 years ago, and I have stayed in this field all my life. In my
studies, I always tried to compare the events of different
disciplines such as genetics, anatomy, bio chemistry and
physiology. I learned that the development of a structure is, under
normal circumstances, strictly determined and that the development
of structures always precedes their proper function. There are no
changes in function without changes in structure. The life of every
cell is genetically preprogrammed and the program may be modified
by complicated interactions with environment. Recent progress in
our knowledge is basicly related to technology. However, using all
the tools of today's technology, we are still unable to understand
the basic normal development. After almost thirty years of work, I
am trying to present a subjective review of the development of the
human endocrine glands. I am presenting an image emerging from my
experience. I personally studied several hundred human embryos
using mostly anatomical, histochemical and some biochemical
techniques. I found much additional information in the literature."
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