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Biology of Cellular Transducing Signals (Paperback, Softcover reprint of the original 1st ed. 1990)
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Biology of Cellular Transducing Signals (Paperback, Softcover reprint of the original 1st ed. 1990)
Series: Gwumc Department of Biochemistry and Molecular Biology Annual Spring Symposia
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Intercellular communication in multicellular organisms enables
cells to respond to environmental changes. Intercellular signal
transduction transmitters include hormones, peptide growth factors,
neurotransmitters as well as some lipid-soluble mediators. Once
signalling molecules are bound to their cell surface receptors, one
or more intracellular signals are generated which alter the
Qehavior of the target cell. The IXth International Washington
Spring Symposium at the George Washington University in Washington,
D.C. was organized to assess the current status of the field of
signal transduction processes and regulatory mechanisms. The
symposium was held on May 8-'.2, 1989 and was attended by more than
1000 scientists from 30 countries. Most of the papers presented at
the plenary sessions have been collected in this volume. The first
section of this book details the action and regulation of receptors
such as ,B-pdr.'nergic receptors and receptors for EGF, insulin,
leukotrienes, phosphoinositides and prostaglandins. Section two
focuses on the family of guanine nucleotide regulatory proteins (G
proteins). These G proteins are known to mediate the coupling of
receptor-mediated signals to several intracellular effector
systems. Papers are presented describing the intracellular
localization of G proteins, the utilization of G protein
antibodies, the interaction of G proteins with tubulin and the
involvement of G proteins in the regulation of ion channels,
adenylate cy~lase and in the activation of neutrophils and T cells.
In the third section, several papers describe the second messenger
role of phosphoinositides as well as the regulation of
phosphoinositide production.
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