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Books > Social sciences > Psychology > Cognition & cognitive psychology
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Brain Aromatase, Estrogens, and Behavior (Hardcover, New)
Loot Price: R4,102
Discovery Miles 41 020
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Brain Aromatase, Estrogens, and Behavior (Hardcover, New)
Series: Oxford Series in Behavioral Neuroendocrinology
Expected to ship within 12 - 17 working days
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It is well known that the class of steroid hormones known as
estrogens have powerful effects on organs related to reproduction
such as the uterus and the breast. What is less well known is that
estrogens also profoundly modulate brain function and behavior.
Estrogens, such as estradiol, can occur in brain as the result of
ovarian secretion of the hormone into the blood that then finds its
way to the brain. In male vertebrates, the testes secrete
androgens, such as testosterone, into the blood and this class of
steroid hormones can be converted into estrogens in the brain via
the action of the enzyme aromatase which is expressed in the male
brain in many species. Finally estradiol can be synthesized de novo
from cholesterol as it has been shown in a variety of species that
all the enzymes required to synthesize estrogens are expressed in
the brain. This book collects chapters by experts in the field that
considers, how estradiol is synthesized in the brain and what its
effects are on a variety of behaviors. Special attention is paid to
the enzyme aromatase that is distributed in discrete regions of the
brain and is highly regulated in a sex specific and seasonal
specific manner. Recently it has become clear that estrogens can
act in the brain at two very different time scales, one is rather
long lasting (days to weeks) and involves the modulation of gene
transcription by the hormone-receptor complex. A second mode of
action is much quicker and involves the action of estrogens on cell
membranes that can result in effects on second messenger systems
and ultimately behavior within minutes. Thus this book highlights
novel views of estrogen action that are still under-appreciated
namely that estrogens have significant effects on the male brain
and that they can act on two very different times scales. This
volume will be of interest to both basic researchers and clinicians
interested in the action of estrogens.
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