The purpose of this book is to bring together scientists and
clinicians interested in oxidative injury in the nervous system but
whose approaches to investigation and treatment design vary widely.
Indeed the goal of this book is to show that the investiga tive
approaches and potential therapeutic interventions perhaps do not
vary as widely as some may think. I think that the readers of this
book will not read it from front to back, but will pick chapters of
interest. Thus, the chapters are organized to contain information
that is essential to understanding basic aspects of oxidative
injury, and thus have some redundancy. However, within the context
of each chapter the reader should hopefully find impetus and
direction to go on to another chapter. The book is divided into
three seetions. The first section contains reviews of metals and
their role in generating oxidative injury. lron is considered in
three of these chapters because of its relative abundance in the
brain and its potency in inducing free radicals. The second section
focuses on mechanisms by which the brain attempts to protect itself
from oxidative injury. Some of these mechanisms have the potential
to be protective in some situations and potentiaIly damaging in
others. The third section contains the clinicaI diseases in which
oxidative injury is known to contribute to the pathogenic process.
This seetion ends with a chapter on antioxidant therapeutic strate
gies in neurological disorders.
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