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Cellular Fatty Acid-binding Proteins (Hardcover, Reprinted from 'MOLECULAR AND CELLULAR BIOCHEMISTRY', 98: 1/2)
Loot Price: R5,523
Discovery Miles 55 230
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Cellular Fatty Acid-binding Proteins (Hardcover, Reprinted from 'MOLECULAR AND CELLULAR BIOCHEMISTRY', 98: 1/2)
Series: Developments in Molecular and Cellular Biochemistry, 6
Expected to ship within 10 - 15 working days
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Twenty years have elapsed since cytoplasmic proteins exhibiting
high-affinity binding of long-chain fatty acids were first
identified (Ockner et al., Science 177:56-58, 1972). These cellular
fatty acid-binding proteins (FABPs) are now well established to
comprise a ligand-defined group of macromolecules belonging to a
family of cytoplasmic lipid binding proteins. Unique features of
the FABPs are the existence of distinct types of FABP and that
these are found in a variety of tissues in remarkable abundance,
with some cells expressing more than one type. The physiological
significance of the FABPs has only partly been elucidated. By
increasing the cytoplasmic solubilization of fatty acids, the
cellular FABPs are considered to function primarily in
intracellular fatty acid transport, but may also be assigned
important regulatory roles in cellular lipid homeostasis as well as
in the modulation of cell growth and differentiation. The broad
interests in cellular FABPs has led to the organization of the 1st
International Workshop on Fatty Acid-Binding Protein, held in
Maastricht, the Netherlands, in 1989. Prompted by the success of
the first meeting, the 2nd International Workshop on
Fatty-Acid-Binding Proteins, which was held again in Maastricht, on
August 31 and September 1, 1992, brought together scientific
scpecialists in the field of FABP research for two days of
intensive and fruitful discussion. This volume is a collection of
selected papers from this conference, and thus provides the
state-of-the-art knowledge of cellular FABPs. The contributors to
this issue represent pioneering as well as new investigators, and
also reflect the multidisciplinary nature of research in this
exciting and rapidly progressing field.
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