As a phylogenetically old system complement is now regarded as a
part of innate immunity. But it is much more than that. It bridges
innate and adapted immunity, participates not only in host defense
but also in many essential physiological processes, old and new
diseases and adverse conditions. Indeed, complement became a term
that almost defies categorization. What was for a long time a
subject for a limited number of specialists has now moved into the
mainstream of experimental and clinical immunology. In 1973 I
visited the Basel Institute of Immunology and met its director, the
eminent scientist and Nobel laureate Nils Jerne. When I entered his
office he greeted me with the following words: "Complement, does
that really exist?" I was never certain whether he wanted only to
tease me or whether he sincerely believed that the complement
system was an unimportant biological curiosity, a misstep of
evolution. But, of course, missteps do not survive the evolutionary
process. Little did I foresee the dramatic developments of recent
years when Hans J. Muller-Eberhard and I started to unravel the
specifics of the action of the cobra venom factor on the complement
system in 1968 and defined a new pathway to its activation. An
elucidation of the role of the system in diseases and its control
for therapeutic reasons is now getting closer to actual realization
in the clinic although many problems, in particular those of highly
specificinhibition free of side effects, have still to be
resolved."
General
| Imprint: |
Springer-Verlag New York
|
| Country of origin: |
United States |
| Release date: |
June 2004 |
| First published: |
2004 |
| Editors: |
Janos Szebeni
|
| Dimensions: |
235 x 155 x 33mm (L x W x T) |
| Format: |
Hardcover
|
| Pages: |
565 |
| Edition: |
2004 ed. |
| ISBN-13: |
978-1-4020-8055-5 |
| Categories: |
Books >
Medicine >
General issues >
General
Promotions
|
| LSN: |
1-4020-8055-7 |
| Barcode: |
9781402080555 |
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