A distinguished panel of internationally recognized neuroscientists
comprehensively review the involvement of and changes in glial
cells both during the normal aging process and in the major
disorders of old age. Topics range from the cellular and molecular
changes that occur with aging-especially aging-associated
activation of astrocytes and microglia and its relation to neuronal
injury and repair-to neuron-glia intercommunication. The
contributors show how glial signals may be modulated by hormones,
growth factors, neurotransmitters, intracellular metabolism, and
intercellular exchanges, as well as by aging of the blood-brain
barrier.
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