Over the last decade, the advent of biologic agents has greatly
revolutionized therapeutic medicine in the management of chronic
inflammatory diseases, such as rheumatoid arthritis, Crohna (TM)s
disease, and psoriasis. Elucidation of the complex web of cytokine
network and the roles of these cytokines in the pathogenesis of
inflammatory disorders provided one of the key catalysts for the
advancement of targeted biologic therapy in autoimmune and
inflammatory diseases.
TNF-alpha is known to play a crucial role in the pathogenesis of
many chronic inflammatory diseases. Elevated levels of TNF-alpha
have been demonstrated in Crohna (TM)s disease, psoriasis,
psoriatic arthritis, and rheumatoid arthritis, suggesting a role
for TNF-alpha in their pathogenesis. Although TNF-alpha plays a
critical role in the activation of innate and acquired immune
responses, the persistence of the immune response and inappropriate
production of TNF-alpha can produce pathological changes resulting
from chronic inflammation and tissue damage.
This volume provides a comprehensive overview of the
development, pharmacology, efficacy, and safety of the currently
available TNF-alpha inhibitors a" etanercept, infliximab, and
adalimumab. The most recent preclinical and clinical data is
presented on this topic, which should be of interest to the
preclinical researcher, the clinician, and the patient who wants to
learn more about these therapies.
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