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Books > Science & Mathematics > Biology, life sciences > Cellular biology
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Cellular Peptide Hormone Synthesis and Secretory Pathways (Hardcover, 2010 Ed.)
Loot Price: R5,454
Discovery Miles 54 540
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Cellular Peptide Hormone Synthesis and Secretory Pathways (Hardcover, 2010 Ed.)
Series: Results and Problems in Cell Differentiation, 50
Expected to ship within 10 - 15 working days
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The concept of hormonal regulation using intercellular peptide
messengers dates back to the discovery of secretin in 1902. The
concept was simple: A peptide is released from specific hormone
producing cells, endocrine cells, into circulation upon stimulation
of the cells. The peptide hormone travels via blood to its target,
the cells of which are equipped with specific receptors for
high-affinity binding of the particular peptide hormone. Receptor
binding subsequently elicits action of the target cells. This
concept has been seriously challenged by modern biochemistry and
cell biology. Thus, it is now well established that the gene of a
specific peptide hormone may be expressed in different types of
endocrine cells, in neurons, and in some instances also in
adipocytes, myocytes, osteoblasts, and immune cells. Today, only a
few hormones - including the old master hormone insulin - represent
the original endocrine paradigm. Instead, the widespread cellular
synthesis now raises the qu- tion of how the body maintains the
regulation of its functions by peptide hormones when a hormone may
originate from a variety of cells.
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