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Single-particle Cryo-electron Microscopy: The Path Toward Atomic Resolution/ Selected Papers Of Joachim Frank With Commentaries (Hardcover)
Loot Price: R5,725
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Single-particle Cryo-electron Microscopy: The Path Toward Atomic Resolution/ Selected Papers Of Joachim Frank With Commentaries (Hardcover)
Series: Series in Structural Biology, 10
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The book reproduces 55 of more than 300 articles written by the
author, representing milestones in methods development of
single-particle cryo-EM as well as important results obtained by
this technique in the study of biological macromolecules and their
interactions. Importantly, neither symmetries nor ordered
arrangements (as in two-dimensional crystals, helical assemblies,
icosahedral viruses) are required. Although the biological
applications are mainly in the area of ribosome structure and
function, the elucidation of membrane channel structures and their
activation and gating mechanisms are represented, as well. The book
is introduced by a commentary that explains the original
development of concepts, describes the contributions of the
author's colleagues and students, and shows how challenges were
overcome as the technique matured. Along the way, the ribosome
served as an example for a macromolecule with intricate structure
and conformational dynamics that pose challenges for
three-dimensional visualization. Toward the end of the book -
bringing us to the present time - molecular structures with
near-atomic resolution are presented, and a novel type of
computational analysis, manifold embedding, is
introduced.Single-particle cryo-EM is currently revolutionizing
structural biology, presenting a powerful alternative to X-ray
crystallography as a means to solve the structure of biological
macromolecules. The book presents in one place a number of articles
containing key advances in mathematical and computational methods
leading up to the present time. Secondly, the development of the
technique over the years is reflected by ever-expanding discoveries
in the field of ribosome structure and function. Thirdly, as all
histories of ideas, the history of concepts pertaining to this new
method of visualization is fascinating all in itself.
General
Imprint: |
World Scientific Publishing Co Pte Ltd
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Country of origin: |
Singapore |
Series: |
Series in Structural Biology, 10 |
Release date: |
May 2018 |
First published: |
2018 |
Editors: |
Joachim Frank
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Dimensions: |
277 x 316 x 31mm (L x W x T) |
Format: |
Hardcover
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Pages: |
580 |
ISBN-13: |
978-981-3234-85-7 |
Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
Molecular biology
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LSN: |
981-3234-85-7 |
Barcode: |
9789813234857 |
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