Innate Immunity has long been regarded as the non-specific arm
of immune response, acting immediately and in a generic way, to
defend the host from infections. In the post genomic era, our
knowledge of the innate immune system is enriched by findings on
the specificity of innate immune reactions as well as to novel
functions that do not strictly correlate with immunological defense
and surveillance, immune modulation or inflammation. Several
studies indicate that molecules involved in innate immunity exert
functions that are either more complex than previously thought, or
go well beyond the innate immune character of the system.
The advent of high-throughput platforms for genome and
proteome-wide profiling, together with the enormous amount of raw
genetic information that has accumulated in the databases, have
stirred new expectations in biomedical research. They have led
scientists to revisit established biological systems from a global
and integrative perspective. Innate Immunity research is now faced
with the challenge of trying to integrate isolated biochemical
pathways into complex gene and protein regulatory circuits. In this
respect, scientists from around the world convened at the 4th
International Conference on Innate Immunity (June 4 - 9, 2006), in
Corfu, Greece to discuss recent advances in this fast evolving
field.
This volume represents a collection of topics on natural killer
cells, mast cells, phagocytes, toll like receptors, complement,
host defense in plants and invertebrates, evasion strategies of
microorganisms, pathophysiology, protein structures, design of
therapeutics, and experimental approaches discussed during the
conference.
General
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