Osteoarthritis is a disease that has been characterised
historically by the focal destruction of cartilaginous tissue and
hence, is defined as such. However, recent investigations have
brought this pathology into contention with significant evidence
implicating subchondral bone in the disease's pathophysiology.
Early-stage primary osteoarthritic bone samples were harvested from
both presenting medial and and non-presenting lateral compartments
of diseased human tibia and were used to investigate the role of
subchondral bone in the pathogenesis of primary human
osteoarthritis. Significant differences in intrinsic tissue
stiffness and mineralisation were observed in all samples
presenting with clinically-defined, early-stage OA. Interstingly,
non-presenting lateral samples also exhibited significant
differences in stiffness and mineralisation. Hence, the presence of
an early, non-presenting stage of OA initiation was observed in the
bone tissue of these samples prior to overlying cartilaginous
tissue damage. In conclusion, the classic 'wear' and 'tear'
definition of this disease is no longer applicable to human knee
OA.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
December 2010 |
First published: |
December 2010 |
Authors: |
John Gleeson
|
Dimensions: |
229 x 152 x 15mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
264 |
ISBN-13: |
978-3-8433-8250-2 |
Categories: |
Books >
Science & Mathematics >
Physics >
Classical mechanics >
General
|
LSN: |
3-8433-8250-6 |
Barcode: |
9783843382502 |
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