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Salmonella Pathogenesis and Progression in the Development of Human & Veterinary Non-Typhoidal Salmonella Vaccines Against Human Salmonellosis (Paperback)
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Salmonella Pathogenesis and Progression in the Development of Human & Veterinary Non-Typhoidal Salmonella Vaccines Against Human Salmonellosis (Paperback)
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The important foodborne zoonotic pathogen non-typhoidal Salmonella
cause gastroenteritis, bacteremia and focal infection in humans.
Salmonella evades the host's immune system through the coordinated
expression of complex arrays of virulence associated-genes. The
dynamics of host-pathogen Salmonella enterica interaction and
infection might enhance the development of novel targeted
preventative measures and drug regimens. However, widespread usage
of antibiotics has led to the emergence of multiple
antibiotic-resistant Salmonella. To avoid this problem, effective
vaccines are developed to control non-typhoidal Salmonella zoonotic
infections. An understanding of how Salmonella enterica spreads and
survives in tissues has very important implications for targeting
intracellular Salmonella with vaccine-induced immune responses.
Application of advanced knowledge and scientific methods in the
development of vaccines could diminish the non-typhoidal Salmonella
disease burden globally. Currently, the oral live attenuated
vaccines showed an efficient protection against non-typhoidal
Salmonella zoonotic infection. However, inactivated or sub-unit
vaccines are considered to be the safest over live vaccines.
Ultimately, this review explores the molecular basis of
non-typhoidal Salmonella pathogenesis. In addition to pathogenesis,
recent advances in generation of Salmonella vaccines are also
emphasised. This review also gives a deep insight into the future
development of Salmonella vaccines with different innovations.
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