Hepatitis delta virus which causes severe acute and chronic
liver disease was discovered following the detection of a novel
antigen-antibody system in hepatitis B virus carriers. Currently,
HDV is classified as a subviral satellite of hepatitis B virus.
However, unlike other satellite viruses, the dependence of HDV on
HBV is limited solely to the provision of an envelope of hepatitis
B surface antigen for virus assembly. Research into the molecular
virology of the HDV life cycle has revealed a fascinating
collection of biology. These insights are now beginning to be
translated into new potential treatment strategies. There are
currently still an estimated 15 million HDV carriers worldwide.
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