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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Targeting the DNA Damage Response for Anti-Cancer Therapy (Hardcover, 1st ed. 2018)
Loot Price: R6,957
Discovery Miles 69 570
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Targeting the DNA Damage Response for Anti-Cancer Therapy (Hardcover, 1st ed. 2018)
Series: Cancer Drug Discovery and Development
Expected to ship within 10 - 15 working days
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Over the past decade a complex role for DNA damage response (DDR)
in tumorigenesis has emerged. A proficient DDR has been shown to be
a primary cause for cellular resistance to the very many DNA
damaging drugs, and IR, that are widely used as standard-of-care
across multiple cancer types. It has also been shown that defects
in this network, predominantly within the ATM mediated signaling
pathway, are commonly observed in cancers and may be a primary
event during tumorigenesis. Such defects may promote a genomically
unstable environment, facilitating the persistence of mutations,
any of which may provide a growth or survival advantage to the
developing tumor. In addition, these somatic defects provide
opportunities to exploit a reliance on remaining repair pathways
for survival, a process which has been termed synthetic lethality.
As a result of all these observations there has been a great
interest in targeting the DDR to provide anti-cancer agents that
may have benefit as monotherapy in cancers with high background DNA
damage levels or as a means to increase the efficacy of DNA
damaging drugs and IR. In this book we will review a series of
important topics that are of great interest to a broad range of
academic, industrial and clinical researchers, including the basic
science of the DDR, its role in tumorigenesis and in dictating
response to DNA damaging drugs and IR. Additionally, we will focus
on the several proteins that have been targeted in attempts to
provide drug candidates, each of which appear to have quite
distinct profiles and could represent very different opportunities
to provide patient benefit.
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