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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Clinical Applications of Cytokines and Growth Factors (Hardcover, 1999 ed.)
Loot Price: R4,766
Discovery Miles 47 660
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Clinical Applications of Cytokines and Growth Factors (Hardcover, 1999 ed.)
Series: Developments in Oncology, 80
Expected to ship within 12 - 19 working days
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The hematopoietic system plays roles that are crucial for survival
of the host: delivery of oxygen to tissues, arrest of accidental
blood leaking from blood vessels, and fending off of invading
microbes by humoral, cell-mediated, and phagocytic immunity. The
activity of the hematopoietic system is staggering: daily, a normal
adult produces approximately 2.5 billion erythrocytes, 2.5 billion
platelets, and 1 billion granulocytes per kilogram of body weight.
This production is adjusted in a timely fashion to changes in
actual needs and can vary from nearly none to many times the normal
rate depending on needs which vary from day to day, or even minute
to minute. In response to a variety of stimuli, the cellular
components of the blood are promptly increased or decreased in
production to maintain appropriate numbers to optimally protect the
host from hypoxia, infection, and hemorrhage. How does this all
happen and happen without over or under responding? There has been
extraordinary growth in our understanding ofhematopoiesis over the
last two decades. Occupying center stage is the pluripotent stern
cell and its progeny. Hematopoietic stern cells have been
characterized by their capacity for self renewal and their ability
to proliferate and differentiate along multiple lineages. Few in
number, the stern cell gives rise to all circulating neutrophils,
erythrocytes, lymphoid cells, and platelets. In hematopoietic
transplantation, the stern cell is capable of restoring long-term
hematopoiesis in a lethally irradiated host.
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