The recent introduction of nanomedicines in the drug therapy
arena is revolutionizing the management of severe diseases. The key
advance in the field is the optimization of the biological fate of
drug molecules, thus improving the therapeutic effect while keeping
to a very minimum the associated toxicity. Volume one of this book
series, "Nanoplatforms in Drug Delivery," established the basic
aspects in the development of drug-loaded nanoplatforms, the
so-called nanomedicines or nanodrugs, focusing on representative
materials and strategies used in their formulation.
Taking advantage of the advanced conceptualizations on
nanomedicine engineering that were described in volume one, volume
two, Nano-Engineering Strategies and Nanomedicines against Severe
Diseases, analyzes in depth special features related to the
formulation of nanoplatforms for oral, dental, topical and
transdermal, pulmonary and nasal, ocular and otic, vaginal, and
brain drug delivery and targeting. Particular aspects of
nanomedicine engineering and "in vivo" fate associated with the
routing of drug administration are given special attention. In
addition, an up-to-date view is presented on the use of
nanomedicines against severe diseases, such as cancer,
cardiovascular diseases, neurodegenerative disorders, infectious
diseases, chronic inflammatory diseases, and metabolic diseases.
The chapters analyze the key factors that need to be controlled to
achieve the optimum therapeutic effect. Attention is further given
to gene delivery and the recent concept of nanotheranosis.
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