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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Cardiac Cell and Gene Transfer (Hardcover, 2003 ed.)
Loot Price: R2,683
Discovery Miles 26 830
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Cardiac Cell and Gene Transfer (Hardcover, 2003 ed.)
Series: Methods in Molecular Biology, 219
Expected to ship within 10 - 15 working days
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Heart disease is the leading cause of death in developed countries.
Recent experimental advances featuring cellular, molecular, and
genetic tools and technologies offer the potential for new
therapeutic strategies directed toward remediation of inherited and
acquired heart diseases. Whether these recent basic science
advances will ultimately translate to clinical efficacy for
patients with heart disease is unknown and is important to
ascertain. Cardiac Cell and Gene Transfer: Principles, Protocols,
and Applications is designed to provide the reader with up-to-date
coverage of a myriad of specific methodo- gies and protocols for
gene and cell transfer to the myocardium. Each chapter features a
"Notes" section that provides useful "how to" problem-solving
insights that are often left unstated in standard published
protocols. Cardiac Cell and Gene Transfer: Principles, Protocols,
and Appli- tions addresses principles and applications of cell and
gene transfer to the heart, including protocols for vector
production and purification. Detailed step-by-step methods and
applications for first/second-generation adenoviral vectors,
adeno-associated vectors, gutted adenoviral vectors, and lentiviral
vectors are included. Additionally, detailed methods for cardiac
cell grafting and transplantation are provided, and these chapters
highlight the prospects of cell-based therapies for cardiac repair.
The book also covers specific in vivo techniques for cardiac gene
transfer, and specifies subsequent cellular and organ-level
physiological assessment techniques and protocols. Accordingly,
this book is designed for basic science and clinical researchers in
the academic, pharmaceutical, and biotechnology sectors of the
cardiovascular community.
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