A panel of leading academic and pharmaceutical investigators takes
stock of the remarkable work that has been accomplished to date
with proteasome inhibitors in cancer, and examines emerging
therapeutic possibilities. The topics range from a discussion of
the chemistry and cell biology of the proteasome and the rationale
for proteasome inhibitors in cancer to a review of current clinical
trials underway. The discussion of rationales for testing
proteasome inhibitors in cancer models covers the role of the
proteasome in NF-kB activation, the combining of conventional
chemotherapy and radiation with proteasome inhibition, notably
PS-341, new proteasome methods of inhibiting viral maturation, and
the role of protesome inhibition in the treatment of AIDS. The
authors also document the development of bortezomib (Velcade (TM))
in Phase I clinical trials and in a multicentered Phase II clinical
trials in patients with relapsed and refractory myeloma.
General
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