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Books > Medicine > Pre-clinical medicine: basic sciences > Anatomy
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Prostaglandins and Control of Vascular Smooth Muscle Cell Proliferation (Paperback, Softcover reprint of the original 1st ed. 1997)
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Prostaglandins and Control of Vascular Smooth Muscle Cell Proliferation (Paperback, Softcover reprint of the original 1st ed. 1997)
Series: Agents and Actions Supplements, 48
Expected to ship within 10 - 15 working days
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Uncontrolled proliferation of vascular smooth muscle cells (SMC) in
response to vessel injury is a problem with a considerable
therapeutic impact. Specifically, restenosis after percutaneous
transluminal coronary angioplasty (PTCA) is a clinical problem
without any effective drug therapy so far. Thus, there is need for
an improved drug therapy but also for an improved understanding of
the pathophysiology of growth control in SMC. Cyclooxygenase
products, such as prostaglandins and thromboxane, are intimately
involved in growth responses. Vasodilatory prostaglandins, such as
PGI, PGE or their analogues, have 2 1 been shown to inhibit SMC
proliferation. There is also evidence for a markedly increased
endogenous prostaglandin production during neointirna formation
under the influence of growth factors which includes induction of
COX-2. These data suggest that prostaglandins might be considered
both targets and tools of growth control. However, there are still
many open questions, including the possible interaction of
prostaglandins with other growth modulating factors, in particular
NO, the intracellular signal transduction pathways and the role of
oxidative stress."
General
| Imprint: |
Birkhauser Verlag AG
|
| Country of origin: |
Switzerland |
| Series: |
Agents and Actions Supplements, 48 |
| Release date: |
March 2012 |
| First published: |
1997 |
| Editors: |
K Schroer
• P. Nev
|
| Dimensions: |
235 x 155 x 7mm (L x W x T) |
| Format: |
Paperback
|
| Pages: |
130 |
| Edition: |
Softcover reprint of the original 1st ed. 1997 |
| ISBN-13: |
978-3-03-487354-3 |
| Categories: |
Books >
Medicine >
Pre-clinical medicine: basic sciences >
Anatomy >
General
Promotions
|
| LSN: |
3-03-487354-9 |
| Barcode: |
9783034873543 |
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