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Quantitative NMR Spectroscopy in Pharmaceuticals (Paperback)
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Quantitative NMR Spectroscopy in Pharmaceuticals (Paperback)
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Over the past fifty years nuclear magnetic resonance spectroscopy,
commonly referred to as NMR, has become the preeminent technique
for structure determination of organic compounds. With developments
in both methodology and instrumentation in the past two decades,
NMR has become one of the most powerful and versatile spectroscopic
techniques for characterization and quantification. An increasing
concern with the well being of individuals and life in general has
led to initiatives for improvements in medicine and the world
environment, and in these areas analytical chemistry has
particularly vital roles to play. Where new drugs or materials with
potential commercial value are synthesized, a complete chemical
characterization may be required involving considerable analytical
work. More than any other analytical method the NMR spectroscopy
provides information about the chemical structure and the dynamics
of organic molecules. NMR spectroscopy is by definition a
quantitative spectroscopic tool because the intensity of a
resonance line is directly proportional to the number of resonant
nuclei (spins). This fact enables accurate and precise
determinations of the amount of substance.
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