Rickettsial diseases have affected humanity since the dawn of
civilization. Despite the advent of effective antibiotic therapy,
humans continue to be afflicted by rickettsial diseases, which
still often go undiagnosed because of their protean clinical
manifestations.
During the past decade, several major developments have occurred
in rickettsiology. With the advent of the newly emerging infections
caused by a number of rickettsias, the re-emerging of old
pathogenic species of rickettsias that cause both old and new
syndromes has helped redefine the level of rickettsial
pathogenicity. The intracellular nature of most rickettsias remains
a mystery although their genome size is close to that of the
free-living neisserias.
Advances in molecular techniques have also helped redefine and
reclassify rickettsias by maintaining some in the order
Rickettsiales and placing others in other bacterial orders. The
latter are still included in rickettsial reviews because of
historical precedence. These molecular advances also help us to
refine our knowledge of rickettsial pathogenesis.
This volume is the first of two volumes to result from the 4th
International Conference on Rickettsiae and Rickettsial Diseases,
in which an effort is made to address and clarify issues from
clinical, diagnostic, epidemiologic, and molecular perspectives
that have remained unsolved in the past. In this volume, several
subdisciplines of rickettsiology are included: genomics and
proteomics, a protocol for naming newly isolated rickettsiae;
bioterrorism; the pathobiology of reckettsial infections including
Q (query) fever, antibiotic resistance, and vaccines; the discovery
of new ricketsiae; and the pathobiology of Ehrlichia and Anaplasma
infections. This volume. along with Century of Rickettsiology,
which will be published in 2006 as an Annals volume, will provide a
complete picture of the world-wide range of work that is currently
being carried out in the field of rickettsiology.
"NOTE: Annals volumes are available for sale as individual books
or as a journal. For information on institutional journal
subscriptions, please visit"
"www.blackwellpublishing.com/nyas."
"ACADEMY MEMBERS Please contact the New York Academy of Sciences
directly to place your order (""www.nyas.org"). Members of the New
York Academy of Science receive full-text access to the Annals
online and discounts on print volumes. Please visit http:
//www.nyas.org/MemberCenter/Join.aspx for more information about
becoming a member.
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