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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Protein Conformational Dynamics (Hardcover, 2014 ed.)
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Protein Conformational Dynamics (Hardcover, 2014 ed.)
Series: Advances in Experimental Medicine and Biology, 805
Expected to ship within 12 - 17 working days
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This book discusses how biological molecules exert their function
and regulate biological processes, with a clear focus on how
conformational dynamics of proteins are critical in this respect.
In the last decade, the advancements in computational biology,
nuclear magnetic resonance including paramagnetic relaxation
enhancement, and fluorescence-based ensemble/single-molecule
techniques have shown that biological molecules (proteins, DNAs and
RNAs) fluctuate under equilibrium conditions. The conformational
and energetic spaces that these fluctuations explore likely contain
active conformations that are critical for their function. More
interestingly, these fluctuations can respond actively to external
cues, which introduces layers of tight regulation on the biological
processes that they dictate. A growing number of studies have
suggested that conformational dynamics of proteins govern their
role in regulating biological functions, examples of this
regulation can be found in signal transduction, molecular
recognition, apoptosis, protein / ion / other molecules
translocation and gene expression. On the experimental side, the
technical advances have offered deep insights into the
conformational motions of a number of proteins. These studies
greatly enrich our knowledge of the interplay between structure and
function. On the theoretical side, novel approaches and detailed
computational simulations have provided powerful tools in the study
of enzyme catalysis, protein / drug design, protein / ion / other
molecule translocation and protein folding/aggregation, to name but
a few. This work contains detailed information, not only on the
conformational motions of biological systems, but also on the
potential governing forces of conformational dynamics (transient
interactions, chemical and physical origins, thermodynamic
properties). New developments in computational simulations will
greatly enhance our understanding of how these molecules function
in various biological events.
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