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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Gene Therapy for Cancer (Hardcover, 2007 ed.)
Loot Price: R5,918
Discovery Miles 59 180
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Gene Therapy for Cancer (Hardcover, 2007 ed.)
Series: Cancer Drug Discovery and Development
Expected to ship within 10 - 15 working days
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The possibility of treating cancer, a disease frequently defined
by
genetic defects, by introducing genes that target these very
alterations has generated tremendous enthusiasm. This enthusiasm,
however, has been tempered by an increasing number of obstacles
to
successful therapy, including vector systems that do not reach
systemic
metastases, therapeutic genes with redundant mechanisms allowing
for
cellular resistance, and toxicities in clinical trials that result
in
premature closure. The three comprehensive sections of this
volume
present currently available cancer gene therapy techniques,
with
specific attention to these trouble spots. Part I describes the
various
aspects of gene delivery including vehicles, or vectors, and
their
respective characteristics and production methods. In Part II,
the
contributors discuss strategies and targets for the treatment
of
cancer, including methods for cell-death therapies, correction
of
underlying genetic defects at the molecular level, and activation
of
the immune system or tumor microenvironment. The contributors
provide a
succinct framework for understanding the basic underlying
oncogenic
changes, which encourages the development of vectors engineered
to
exploit these gene mutations through selective spread of the vector
in
tumor cells with the specific changes. Finally, in Part III,
experts in
clinical gene therapy trials discuss the difficulties inherent
in
bringing gene therapy treatment for cancer to the clinic, and
principal
investigators present gene therapy approaches in the clinical
testing
stage and the results that have reached the stage ofclinical
testing.of these trials.
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