The Parvoviridae have been of increasing interest to reseachers in
the past decade. Their small size and simple structure have made
them ame- nable to detailed physiochemical analysis, and from this
work relatively detailed information has resulted that has
signficantly increased our un- derstanding of the biology of these
viruses. It has become clear that the Parvoviridae are of interest
not only for their own sake, but also because their relative
simplicity renders them useful probes in the study of the biology
of host cells and of other DNA viruses with which they interact.
The Dependovirus genus, for instance, contains the defective
adeno-as- sociated viruses (AA V), which require a coinfection with
either an ad- enovirus or a herpesvirus for productive
multiplication. Studies of AA V, therefore, necessarily impinge on
our understanding of the control of macromolecular synthesis by the
helper virus. Similarly AA V has been reported to inhibit the
oncogenicity of both adeno-and herpesviruses and has been used as a
probe of mechanism in these instances as well. Finally, AA V
establishes latent infections in vivo and is the only mammalian DNA
virus where a comparable model system has been established in cell
culture. This system has allowed study of the mechanism of latent
infection at the molecular level.
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