Alzheimer s Disease is the most common form of dementia. The
disease is characterised by the loss of synapses and neurons in the
cerebral cortexand certain subcortical regions. In the last three
years, the genetics of Alzheimer s Disease has made significant
advances; in fact, one could argue more than in the previous two
decades. This has resulted in the identification of nine new genes
and perhaps more importantly the realization that new pathways
could be involved in the pathogenesis of Alzheimer s. These new
pathways are now legitimate targets for therapeutic intervention,
which can possibly lead to treatment or a possible cure. The aim of
this book is to put all of the recent genetic data on these new
genes into context. Different genetic variants will be discussed,
as well as biomarkers and future possibilities.
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