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Carbohydrate-Based Interactions at the Molecular and the Cellular Level (Hardcover, 1st ed. 2018)
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Carbohydrate-Based Interactions at the Molecular and the Cellular Level (Hardcover, 1st ed. 2018)
Series: Springer Theses
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Total price: R3,296
Discovery Miles: 32 960
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This book offers a clearly written and highly accessible account of
two different aspects of carbohydrate chemistry. Carbohydrates are
an essential component of life and have many important biological
functions, but the details of how carbohydrates interact with other
biomolecules to mediate biological signalling remain unclear.
Firstly, this thesis details innovative methods to mine protein
structural data to uncover new features of carbohydrate-based
interactions. It also explains these findings using physical
chemistry, specifically CH-pi interactions associated with the
properties of the interacting partners. Carbohydrates are also
critical for tissue growth and development, yet are underexploited
in the materials science that underpins much of regenerative
medicine. As such, the second part of this thesis describes a
diverse array of techniques ranging from synthetic chemistry and
enzymatic synthesis to prepare a wide variety of carbohydrates, and
materials chemistry to prepare glycosylated hydrogels, to cell
biology to determine the effects on cellular development for tissue
engineering applications.
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