RNA Interference (RNAi) technology has rapidly become one of the
key methods used in functional genomics. RNAi is used to block the
expression of genes and create phenotypes that can potentially
yield clues about the function of these genes. In the postgenomic
era, the elucidation of the physiological function of genes has
become the rate-limiting step in the quest to develop 'gene-based
drugs' and RNAi could potentially play a pivotal role in the
validation of such novel drugs. In this 2005 overview, the basic
concepts and applications of RNAi biology are discussed. Leading
experts from both academia and industry have contributed to this
invaluable reference. The volume is forwarded by Andrew Fire, one
of the winners of the 2006 Nobel Prize for the discovery of RNA
Interference.
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