Cervical cancer is one of the most common malignant diseases
affecting women worldwide. Studies on loss of heterozygosity have
been made for PTEN gene specific microsatellite markers in
malignancies like breast, ovary and lungs and the results have
shown a significant association. However the role of this gene is
not clearly understood in cervical cancer from Indian population. A
total of 135 cervical carcinoma tissues samples were analyzed for
loss of heterozygosity. DNA was isolated from the samples and their
matched control specimens. Polymerase chain reaction was performed
using primer specific for two intragenic markers and one marker in
flanking region and further electrophoresed on 8% denaturing
polyacrylamide gel. Overall, 31 out of 133(23%) informative cases
showed loss of heterozygosity in at least one locus in the region
examined. The percentage of loss of heterozygosity for these
markers ranged from 8% to 13%. Loss of heterozygosity was more
frequently detected in intragenic region than in flanking region.
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