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Adult Stem Cells (Hardcover, 2004 ed.)
Loot Price: R5,492
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Adult Stem Cells (Hardcover, 2004 ed.)
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Studies on stem cells have been attracting intense scientific and
p- lic attention, not only because of controversies surrounding the
use of embryonic stem cells but also because of very provocative
data that have been emerging on adult stem cells. Much of the
public attention and debate has been focused on the possibility
that adult stem cells may be used as a substitute for human
embryonic stem cells or as a justification for stopping work on
them. This has somewhat dim- ished attention on very heated
scientific debates that take us to the very heart of how the
concept of stem cells is perceived. To this author, the latter
debates have not been unlike certain philosophical debates of the
last century. Since the seminal studies of Till and McCulloch in
the 1960s, the popular paradigm on adult stem cells has been that
lineage-restricted stem cells are derived from pluripotent stem
cells very early during development. To many, and consistent with
much data, the restriction to particular lineages was considered
absolute. In other words, there was a sense of determinism in the
stem quality of particular stem cells: once they were allocated,
they were programmed to specific roles in a given tissue.
Furthermore, some adult tissues were considered devoid of
detectable stem cell presence or activity.
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