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Nmr With Biological Macromolecules In Solution: A Selection Of Papers Published From 1996 To 2020 By Kurt Wuthrich (Paperback)
Loot Price: R1,738
Discovery Miles 17 380
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Nmr With Biological Macromolecules In Solution: A Selection Of Papers Published From 1996 To 2020 By Kurt Wuthrich (Paperback)
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The book provides insights into the research of the Kurt Wuthrich
laboratories from 1996-2020. During this time period, the technique
of nuclear magnetic resonance (NMR) spectroscopy in solution went
through several breakthroughs, while maturing into a standard
method of structural biology. With the introduction of TROSY
(transverse relaxation-optimized spectroscopy), the range of
accessible molecular sizes was extended about thirty-fold, and
efficient protein structure determination resulted from the demands
of the structural genomics initiative. Applications in fundamental
biology and biomedicine include studies of prion proteins and prion
diseases (TSEs), the SARS-Corona virus proteome, trans-membrane
signalling by G protein-coupled receptors (GPCRs), and signal
transfer by pheromones.Key publications from the Kurt Wuthrich
laboratories are placed in perspective, providing insights into new
aspects of NMR spectroscopy in structural biology. In addition to
methods development, this includes applications in diverse areas of
biological research, such as prion proteins and their role in
transmissible spongiform encephalopathies (TSEs), trans-membrane
signal transfer by G protein-coupled receptors (GPCRs), structural
characterization of the SARS-Corona virus proteome , metabolic-flux
profiling in bacterial cultures, and signal transfers by
pheromones.
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