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Histological Typing of Tumours of the Central Nervous System (Paperback, 2nd ed.)
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Histological Typing of Tumours of the Central Nervous System (Paperback, 2nd ed.)
Series: WHO. World Health Organization. International Histological Classification of Tumours
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Although more than 12 years have passed since publication of the
first WHO histological classification of central nervous system
(CNS) tumours, the changes in this revised edition are not radical.
Only one formerly recognized entity has been deleted: the
monstrocellular sarcoma, because there is immuno- cytochemical
evidence of its astrocytic nature. Several new tumour types have
been added: the pleomorphic xanthoastro- cytoma has been generally
acknowledged for almost a decade; the neurocytoma has gradually
evolved as a clinical-pathological entity; and two new entries, the
dysembryoplastic neuroepi- thelial tumour and the desmoplastic
infantile ganglioglioma, have only been characterized
morphologically during the past few years. We regard the
classification as an international standard to facilitate
communication and have tried to avoid current con- ceptual
controversies. The majority of partiCipants supported inclusion of
the term "primitive neuroectodermal tumour" (pNET). However,
because of our limited knowledge of the biol- ogy of embryonal CNS
tumours, preference was given to use PNET selectively, rather than
applying it to all small cell embryo- nal childhood tumours,
irrespective of their histological pheno- type. Ependymomas and
meningiomas now have new histological SUbtypes. Most of these are
not associated with biological behaviour different from the parent
tumour type, but their description will aid the practising
pathologist to identify and classify these lesions. 2 Introduction
Histological Typing Following the philosophy of this WHO series,
classification is based primarily on histological assessment of
cell types and tis- sue patterns recognized by conventional light
microscopy.
General
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