Cardiac Rate and Rhythm - Physiological, Morphological and Developmental Aspects (Paperback, Softcover reprint of the original 1st ed. 1982)

In the denervated state the mammalian heart, both in vivo and in vitro, is excited at very regular intervals, the coefficient of variance of the interbeat intervals not exceeding 2%. The pacemaker that is the source of this regular ex citation is localised normally within the sinus node (" sino-atrial node " node of Keith and Flack), a most intriguing small piece of tissue in the caval corner of the right atrium. A small portion of this node containing a group of probably only a few thousands of cells fires spontaneously, that means without any exter nal influence to trigger their activity. The so called pacemaker cells do this by letting their membrane potential fall to the level where an action potential will start which subsequently activates surrounding cells to fire an action po tential. The first question which is tackled in this book is which processes underly this spontaneous diastolic depolarization. This is discussed in section I, concerning the fundamental properties of pacemaker cells with special refer ence to ionic membrane currents. Although views still quite differ about the exact nature of the membrane processes that cause the automatic pacemaker dis charge there is agreement that diastolic depolarization is brought about by the interaction of a number of ionic current systems, including both inward and out ward going currents."

General

Imprint:	Springer
Country of origin:	Netherlands
Series:	Developments in Cardiovascular Medicine, 17
Release date:	October 2011
First published:	1982
Editors:	L.N. Bouman • H. Jongsma
Dimensions:	235 x 155 x 35mm (L x W x T)
Format:	Paperback
Pages:	696
Edition:	Softcover reprint of the original 1st ed. 1982
ISBN-13:	978-9400975378
Categories:	Books > Medicine > Clinical & internal medicine > Cardiovascular medicine Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Vertebrates > Mammals > General
LSN:	9400975376
Barcode:	9789400975378

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