Cell fusions are important to fertilization, placentation,
development of skeletal muscle and bone, calcium homeostasis and
the immune defence system. Additionally, cell fusions participate
in tissue repair and may be important to cancer development,
progression and therapy. A large number of factors regulate cell
fusions, including receptors and ligands, membrane domain
organizing proteins, proteases, signaling molecules and fusogenic
proteins that bring membranes close together. In the present
volume, we interrogate what mechanisms that may be important to
cell fusions in mammals and what mechanisms that may be shared with
lower organisms and viruses. Additionally, the importance of cell
fusions to the pathogenesis as well as treatment of diseases is
addressed.
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