The terms pharmacogenomics and pharmacogenetics tend to be used
interchangeably, and a precise, consensus definition of either
remains elusive. Pharmacogenetics is generally regarded as the
study of genetic variation that gives rise to differing response to
drugs, while pharmacogenomics is the broader application of genomic
technologies to new drug discovery and further characterisation of
older drugs. Pharmacogenetics considers one or at most a few genes
of interest, while pharmacogenomics considers the entire genome.
Much of current clinical interest is at the level of
pharmacogenetics, involving variation in genes involved in drug
metabolism with a particular emphasis on improving drug safety.
This book presents leading-edge research in this dynamic field.
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