Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Protein Delivery - Physical Systems (Paperback, Softcover reprint of the original 1st ed. 1997)
Loot Price: R5,685
Discovery Miles 56 850
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Protein Delivery - Physical Systems (Paperback, Softcover reprint of the original 1st ed. 1997)
Series: Pharmaceutical Biotechnology, 10
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Protein and peptide therapeutics currently represent eight of the
top 100 prescription pharmaceuticals in the U.S., and biotechnology
products are projected to account for 15% of the total US.
prescription drug market by 2003. Of the protein and peptide
products now on the market, many are administered as daily
injections, though several are deliveredby noninvasive routes. For
example, desmopressin is delivered as a nasal spray, and
deoxyribonuclease I is administered by inhalation. Although
cyclosporin A is orally active, as yet there are no general means
to confer oral bioava- ability to peptides and proteins. A major
advance in delivery ofpeptides was achieved with the introduction
of a monthly injectable, biodegradable microsphere formulation of
LHRH. Despite the enormous success of biotechnology products to
date, much effort continues to be focused on the development of
more convenient and noninvasive routes of administration for those
products that require f- quent and prolonged dosing. Here we
present an overview of the te- nologies, both developed and
emerging, which are applicable to protein delivery. In addition,
chapters 11 through 13 detail case studies on physical methods for
delivery ofinsulin and growth hormone
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